I'm probably the only geek thats played this game but we'll see. I'm playin Sherlock Holmes Nemesis, and I've made it all the way to the investigation of the break in at the art museum. I have found the back rooms with the open skylight, the footprints in paint, and the red square painted on the floor, as well as the thing that appears to be a letter stuck to the ceiling of one of the art rooms, but now I'm stuck. I'm just wanderin around waiting for Watson to get back with a ladder. Is there something else I am supposed to find? I've checked every nook and cranny, and looked at all the ceilings, and examined the walls and paintings of every room, and its driving me crazy.
If anyone has played this game please help me!
Hello, fellow geek! 
I find it really fun, though. My head nearly exploded when I realized I got to walk around in a replica of the National Gallery in the 19th century. 
I spent hours walking around and pondering over every single picture and listening to Holmes' little info about it, like I was in my own private art museum. And then you get to go to the Tower of London and the British Museum, not to mention Baker Street itself! Awesomeness. 
Have you played Sherlock Holmes vs. Jack the Ripper? It's the next game they made after Nemesis, I believe, and it has a really spooky recreation of a section of Whitechapel.